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KMID : 1013220060040010073
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Jouranl of the Korean Society of Clinical Toxicology
2006 Volume.4 No. 1 p.73 ~ p.77
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Severe Liver Toxicity Caused by Amatoxin (Case Series)
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Suh Joo-Hyun
Kim Sung-Jin
Chung Young-Kuk
Choi Woong-Gil
Kwon Young-Se
Roh Hyung-Keun
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Abstract
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Poisoning with mushroom containing amatoxin may be a real medical emergency and is characterized by long incubation time lag, gastrointestinal symptoms, hepatotoxic phase and sometimes death. We report a family of parents and two children who ingested wild mushroom and recovered from varying degrees of hepatotoxicity. After eating cooked wild mushroom and its soup, they all developed abdominal pain, vomiting and diarrhea 11 hours later, Their liver enzymes reached peak level between 48 and 72 hours after the ingestion. Among the family members, 5-year-old girl showed the most severe hepatic toxicity of AST/ALT 14,099/13,176 IU/L. They were all treated with supportive measures including repeated activated charcoal and penicillin G and recovered from the hepatotoxicity between 7 and 28 days after the ingestion. Being based on the shape and a typical course of the amatoxin poisoning, we presume that this wild mushroom belongs to Amanita virosa.
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KEYWORD
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Amatoxin, Amanita virosa, Hepatotoxicity
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